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Novel Factors Research Program

In our largest single donation to date, the RMS Foundation donated $30,000 to fully fund a research proposal specific to esophageal cancer lead by Dr. Lindsay Puckett and Dr. Michele Battle of  the Medical College of Wisconsin. 

The research program presented to the RMS Foundation is considered a “Pull The String” research pilot program, and by fully funding the pilot program it opens the door for additional funding through grants and other sources. This research program is designed to test, investigate and identify the novel factors and pathways that are associated with Esophageal Cancer. Which is why we are using the phrase “Pull The String.” Through RNA Sequencing, the research team will identify pathways and start to pull the string to see what will unravel that may lead to patterns, diagnosis, improved treatment and therapy, and a possible cure. 

How will it start??

Using the state-of-the-art technique of RNA-sequencing, the team will comprehensively delineate the molecular landscape of esophageal tumors and metastatic lesions. In connection with Dr. Michele Battle’s basic science lab, the team has identified 47 specimens already available for RNA-sequencing and examination to begin in the immediate future.

Long Term Goal??

Using what the team learns, the hope is to develop clinical trials to offer a more personalized and efficacious approach to esophageal cancer treatment. The team hypothesizes that this would likely include gathering a patient’s molecular information from an initial biopsy (before the patient undergoes treatment) and then tailoring the ultimate treatment plan to that specific individual for a drastically improved chance of survival. 

A core mission of the RMS Foundation is to advance Esophageal Cancer research, with this new partnership and research program we are taking the right steps forward. 

We will continue to share updates as the research progresses!

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The "battle Lab"

This is where the “Pull The String” research program is taking place. We couldn’t think of a cooler or more fitting name for the lab that is supporting this research. If you would like to learn more about the “Battle Lab” and the incredible team check out this video! 

Battle Lab Tour

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The Battle Lab Team

From Left to Right: Ella Metten - Research Technologist, Defining mechanisms of gastric cancer; Joe Raasch - Research Technologist, Defining mechanisms of gastric cancer; Dr. Michelle Battle - Dept. of Cell Biology, Neurobiology, and Anatomy; Jess Gawrys - Research Technologist, Defining mechanisms of esophageal cancer; Olivia Franklin - Graduate Student, Defining mechanisms of esophageal cancer

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